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  • Chemotherapy is assuming an increasingly important role in the treatment of malignant gliomas,,.
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    Furthermore, analytical epidemiologic studies indicate that the incidence of these tumors is steadily increasing in children and adults,. The cause of this increase in incidence currently remains unknown. High grade malignant gliomas WHO grades III and IV are characterized by high levels of proliferative, migratory and invasion activities as well as high resistance to treatment.

    These hallmarks typify the aggressive tumor phenotype and account for the very poor prognosis and as yet, the incurable nature of the disease. Treatments of patients with malignant gliomas thus remain palliative and generally include surgery, radiotherapy, and chemotherapy in various combinations.

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